Africa’s High Level Policy Dialogue (HPLD) on Science, Technology and Innovation agreed to work towards a long term jointly funded and co-owned research and innovation partnership with, as a first priority, the role of science, technology and innovation in ensuring “Food security and nutrition security and sustainable agriculture”. HLPD tasked an expert working group to prepare this roadmap and set out short, medium and long-term milestones recognising the important cross-cutting nature of innovation, entrepreneurship, research infrastructures and technical competence strengthening.